cycling home from mass ave. sometimes i wish there is "pintu sukati hati aku lah" when i get too tired from the day. or whenever i feel like to eat and spend the whole evening sleeping until the next morning. sounds platonic, eh. my relationship with sleep is even worse than iceland prime minister's love hate relationship with pineapple pizza. i'd love to write about Murphy's Law but i am really lazy to think about it after spending hours reading on crystallinity and physics - oh god why i never paid attention to glass transition and melting temperature before. this behavior could be the answer for human tissue regeneration. reading Prof. yannas's paper, published in 1967 on gelatin glass transition and melting temperature - and corrected flory's work on the same topic - gave a hard bitch slap on my pretty face. i didn't know that this was important. i couldn't care less about dilatometer because we have TGA and DSC, and powerful 400Hz NMR machine - or matrix assisted laser dilapidated ionization time of flight to determine the crystallinity and molecular packing in the polymer. i wasn't paying attention to the physics - it was always someone else's job. i just wanted my number and get away with it. that was the reason why biomaterials do not work in organ regeneration. i admit, my ignorance failed me this time. Prof asked if i ever looked into the structure and understand the evolution of material (collagen) over thousands of years - making it stable and the best candidate for organ regeneration. the answer lies in the crystallinity, packing order, band formation and number of binding site for the protein (integrin) as many scientists in this era did not look into this and only replicate the morphology and structural features.
that answer my ten year quest working with natural and synthetic polymers for organ regeneration - from alginate, to gelatin, glucomannan, xanthan, collagen, 9gag, chitosan and fibrin glue. i bought the idea that nature has abundance supplies for organ regeneration - due to evolution transcended over myr of years, we may share the same traits and structure that can be useful to treat organ defect and support human's ability to regenerate and heal. in fact, i only got it half right and it was not good enough for organ regeneration.
the Murphy's Law - that anything could happen, and possible if you can think about it - doesn't really work.
because thinking without reasoning and understanding the fundamental physics can be futile and wasting time. (although you may want to think that time isn't real, it is just passing of events).
